Lumvoa™ (veligrotug-vvze) is administered as 5 infusions over 12 weeks1
Quick preparation and administration guide for Lumvoa
For full instructions on administering Lumvoa, please download the guide below.
How supplied
Lumvoa is supplied as a sterile, preservative-free solution in a single-dose, 10 mL vial containing 500 mg of veligrotug-vvze (50 mg/mL). Refrigerate at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze or shake.
Prepare
No reconstitution is required. Lumvoa is supplied as a ready-to-dilute solution. Calculate the number of vials needed based on the patient's weight for the 10 mg/kg dose.
Dilute
Using a 250 mL bag of 0.9% sodium chloride injection, USP, withdraw and discard a volume of saline equal to the volume of Lumvoa to be added. Withdraw the required volume from the Lumvoa vial(s) and transfer into the infusion bag. Mix by gentle inversion.
Do not shake. Do not freeze the diluted solution. Discard vial(s) and all unused contents.
Infuse
Administer the first infusion over 45 minutes. If well tolerated, subsequent infusions may be administered over at least 30 minutes; otherwise, infuse over 45 minutes. Do not administer as an IV push or bolus.
Lumvoa should not be infused concomitantly with other agents.
Inspect the diluted solution visually for particulate matter and discoloration prior to administration. Discard if particulate matter or discoloration is observed.
Lumvoa may cause infusion reactions, which have been reported in approximately 9% of patients treated with Lumvoa. Signs and symptoms of infusion-related reactions include transient increases in blood pressure, fever, chills, headache, and fatigue. Infusion reactions may occur during or soon after an infusion. Reported infusion reactions are usually mild or moderate in severity and can usually be successfully managed with corticosteroids, antihistamines, and antipyretics. In patients who experience an infusion reaction, consideration should be given to standard premedication and/or administering infusions at a slower infusion rate.